Neuropharmacological evaluation of ethanol leaf extract of Zea mays

  • Jude Efiom Okokon University of Uyo, Uyo, Nigeria
  • Anwangabasi E Udoh Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Jackson Obot Department of Pharmacology and Therapeutics, Faculty of Clinical Sciences, University of Uyo, Uyo, Nigeria
  • Louis U Amazu Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu campus, Imo State, Nigeria
Keywords: Zea mays, CNS stimulant, Open field test, Forced swimming test, Tail suspension test

Abstract

The ethanol leaf extract of Zea mays (170 - 510 mg/kg) was investigated for effect on the central nervous system (CNS) using open field, forced swimming, and tail suspension tests using mice. The extract was found to significantly (p < 0.05-0.01) increase the frequency of line crossing, rearing and walling activities of mice in open field test. The extract also decreased significantly (p < 0.05-0.001) the duration of immobility time of mice in forced swimming and tail suspension tests. The results of this study show that the leaf extract of Z. mays has CNS stimulatory activity and this justify its use in ethnomedicine for the treatment of central nervous system disorders.

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Published
2018-12-24
How to Cite
Okokon, J. E., Udoh, A. E., Obot, J., & Amazu, L. U. (2018). Neuropharmacological evaluation of ethanol leaf extract of Zea mays. Journal of Basic Pharmacology and Toxicology, 2(2), 11-14. Retrieved from http://scigreen.com/index.php/JBPT/article/view/51
Issue
Vol. 2 No. 2 (2018)
Section
Original Research Articles

Copyright (c) 2018 Jude Efiom Okokon, Anwangabasi E Udoh, Jackson Obot, Louis U Amazu

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).