Neuropharmacological evaluation of ethanol leaf extract of Zea mays
AbstractThe ethanol leaf extract of Zea mays (170 - 510 mg/kg) was investigated for effect on the central nervous system (CNS) using open field, forced swimming, and tail suspension tests using mice. The extract was found to significantly (p < 0.05-0.01) increase the frequency of line crossing, rearing and walling activities of mice in open field test. The extract also decreased significantly (p < 0.05-0.001) the duration of immobility time of mice in forced swimming and tail suspension tests. The results of this study show that the leaf extract of Z. mays has CNS stimulatory activity and this justify its use in ethnomedicine for the treatment of central nervous system disorders.
Copyright (c) 2018 Jude Efiom Okokon, Anwangabasi E Udoh, Jackson Obot, Louis U Amazu
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© 2017 The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).