Journal of Basic Pharmacology and Toxicology 2018-05-19T07:58:01+00:00 Dr. Mohamed Saleem, PhD Open Journal Systems <p>The Journal of Basic Pharmacology and Toxicology is a quarterly peer-reviewed open access journal, publishes peer-reviewed original research and review articles in the areas of basic pharmacological and toxicological&nbsp;evaluations of natural crude extracts, isolated compounds and synthetic drugs <em>in vivo</em>, <em>in vitro</em>, <em>ex vivo</em> and <em>in silico</em>. The pharmacological evaluations include but not limited to basic pharmacological experiments such as antioxidant activity, antiulcer activity, antidiabetic activity, analgesic activity, anti-inflammatory activity and antinociceptive activity. The toxicological evaluations include acute and chronic toxicity evaluations including histopathological&nbsp;and immunohistochemical studies. The journal welcomes human and animal studies.</p> Synthesis and biological evaluation of sulphonyl derivatives of naturally occurring chromone alkaloid of rohitukine as anticancer agents 2018-05-19T07:53:54+00:00 Sunil K Mishra Pallavi Srivastava S K Rath A A Mahdi S K Agarwal Vijai Lakshmi <p>The present study deals with isolation of active constituent, rohitukine from the stem bark of <em>Dysoxylum binectariferum</em>, and synthesis of a series of its new sulphonyl derivatives aiming to enhance its therapeutic efficacy. Rohitukine has been isolated with more than 95% purity and ten new semisynthetic analogs have been prepared using different sulphonyl chlorides. These derivatives were evaluated for anticancer activity against MCF-7 (ER +ve) and MDA-MB-231 (ER -ve) breast cancer cell lines. Compounds K6, K8 and K10 showed significant activity against breast cancer cell lines at a concentration of 17.5 µM, 17 µM and 19 µM in MCF-7 and 20 µM, 9.8 µM and 28.5 µM in MDA-MB-231 respectively. These compounds induced significant apoptosis in MCF-cell line. Further work may enhance the anticancer activity.</p> 2018-01-20T00:00:00+00:00 ##submission.copyrightStatement## Antibacterial and synergistic potency of methanolic leaf extract of Ocimum gratissimum L. and Vernonia amygdalina L. 2018-05-19T07:53:54+00:00 Sylvester Chibueze Izah E.J. Uhunmwangho Nsikak Godwin Etim <p><em>Vernonia amygdalina </em>and <em>Ocimum gratissimum </em>are common perennial shrubs that are used as vegetables and spices. Studies have indicated that both plants have several medicinal properties. This study investigated the antibacterial and synergistic potency of methanolic leaf extracts of <em>Vernonia amygdalina </em>and <em>Ocimum gratissimum</em>. The leaf samples were shade dried, extracted using methanol and tested against some bacterial isolates using agar well diffusion method. The mean zone of inhibition against <em>E. coli</em>, <em>Staphylococcus aureus</em> and<em> Bacillus </em>sp. was 13.67 mm, 13.33 mm and 13.00 mm, respectively by <em>V. amygdalina</em>, 13.00 mm, 12.67 mm and 13.00 mm, respectively by <em>O. gratissimum, </em>and 15.00 mm, 13.67 mm, 13.33 mm, respectively for synergy of <em>V. amygdalina </em>and <em>O. gratissimum </em>at 100% concentration. There was no significant variation (<em>p</em> &gt; 0.05) among the various isolates, and plants and its combinations at 100% and 85% concentrations, but significant difference (<em>p</em> &lt; 0.05) exists at 95% and 90% extracts. The findings showed that the combination had slight superior potency against the tested isolates.</p> 2018-01-20T00:00:00+00:00 ##submission.copyrightStatement## Antibacterial and synergistic efficacy of acetone extracts of Garcinia kola (Bitter kola) and Buchholzia coriacea (Wonderful kola) 2018-05-19T07:58:01+00:00 Lovet T Kigigha Remita E Selekere Sylvester Chibueze Izah <p>This study investigated the antibacterial and synergistic efficacy of acetone extracts of seed of <em>Buchholzia coriacea </em>(wonderful kola) and <em>Garcinia kola </em>(bitter kola). Extraction was carried out using acetone, and Agar well diffusion sensitivity testing method was adopted. Results showed that the highest zone of inhibition was achieved when both kola was mixed at ratio of 1:1. The zone of inhibition of synergy extract of <em>Garcinia kola </em>nut and <em>Buchholzia coriacea </em>seed for <em>E. coli, Pseudomonas sp, Staphylococcus aureus</em> and <em>Bacillus </em>sp were 14.00 mm, 12.33 mm, 13.0 mm and 12.00 mm respectively. Furthermore, individual zones of inhibition for <em>E. coli, Pseudomonas </em>sp.<em>, Staphylococcus aureus</em> and <em>Bacillus </em>sp. were 11.33 mm, 9.67 mm, 13.67 mm and 11.00 mm respectively for <em>Buchholzia coriacea</em> and 13.00 mm, 11.00 mm, 13.0 mm and 12.67 mm respectively for <em>Garcinia kola.</em> Analysis of variance showed that there was no significant difference (<em>p</em> &gt; 0.05) among the different isolate for the different extracts except for that of <em>Buchholzia coriacea. </em>This study showed that synergistic efficacy of bitter kola and wonderful kola produced superior antimicrobial effects. Again, the positive result for both gram negative bacteria (<em>E. coli, Pseudomonas </em>sp.) and gram positive bacteria (<em>Staphylococcus aureus</em> and <em>Bacillus </em>sp.) suggest that they could be used as broad spectrum antibiotics.</p> 2018-01-20T00:00:00+00:00 ##submission.copyrightStatement##