Anticonvulsant activity of corn silk (Stigma maydis)
AbstractCorn silk of Zea mays L. (Stigma maydis) (Family: Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol corn silk extract of Z. mays (170 - 510 mg/kg) was investigated for anticonvulsant activity in mice using pentylene tetrazol and aminophylline-induced convulsion models to assess anticonvulsant activity. The extract was found to significantly (p < 0.005 -0.01) offer protection against PTZ- and aminophylline-induced convulsions in mice. The corn silk extract of Z. mays possesses anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.
Copyright (c) 2018 Jude Efiom Okokon, Koofreh Davies, Emmanuel E Nyong, Anwangabasi E Udoh
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© 2017 The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).