Anticonvulsant activity of corn silk (Stigma maydis)

  • Jude Efiom Okokon University of Uyo, Uyo, Nigeria
  • Koofreh Davies Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
  • Emmanuel E Nyong Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Anwangabasi E Udoh Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
Keywords: Zea mays, cornsilk, anticonvulsant

Abstract

Corn silk of Zea mays L. (Stigma maydis) (Family: Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol corn silk extract of Z. mays (170 - 510 mg/kg) was investigated for anticonvulsant activity in mice using pentylene tetrazol and aminophylline-induced convulsion models to assess anticonvulsant activity. The extract was found to significantly (p < 0.005 -0.01) offer protection against PTZ- and aminophylline-induced convulsions in mice. The corn silk extract of Z. mays possesses anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.
Published
2018-12-24
How to Cite
Okokon, J. E., Davies, K., Nyong, E. E., & Udoh, A. E. (2018). Anticonvulsant activity of corn silk (Stigma maydis). Journal of Basic Pharmacology and Toxicology, 2(2), 6-10. Retrieved from http://scigreen.com/index.php/JBPT/article/view/49
Section
Original Research Articles