Effects of a tincture of Citrus aurantium on isolated vascular tissues from rats

  • Loipa Galán Martínez Laboratorio de Electrofisiología Básica. Departamento Docencia-Investigaciones. Instituto de Cardiología y Cirugía Cardiovascular, 17 N° 702, Vedado, La Habana, Cuba.
Keywords: aortic rings, bitter orange, Citrus aurantium L., herbal medicine, vasorelaxation

Abstract

Citrus aurantium (bitter orange) is used as medicinal herb in many disorders. The peel of C. aurantium fruit tincture-induced vascular effects were investigated in endothelium-denuded rat aortic rings precontracted with 60 mmol/L of KCl. This tincture at low concentrations did not produce significant vascular effects, but from 10 to 100 mg/mL, it has produced a vasorelaxing effect. The maximal relaxant effect of C. aurantium peel tincture was 87.52 ± 3.51% at a concentration of 100 mg/mL (p < 0.05; n = 4). The concentration of this tincture necessary to reduce KCl-induced contractions of the endothelium-denuded aorta by 50% was 18.36 ± 0.72 mg/mL.

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Published
2021-05-10
How to Cite
Galán Martínez, L. (2021). Effects of a tincture of Citrus aurantium on isolated vascular tissues from rats. Journal of Basic Pharmacology and Toxicology, 5(1), 10-13. Retrieved from https://scigreen.com/index.php/JBPT/article/view/79
Section
Original Research Articles