Anticonvulsant activity of corn silk (Stigma maydis)

  • Jude Efiom Okokon University of Uyo, Uyo, Nigeria
  • Koofreh Davies Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
  • Emmanuel E Nyong Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Anwangabasi E Udoh Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
Keywords: Zea mays, cornsilk, anticonvulsant

Abstract

Corn silk of Zea mays L. (Stigma maydis) (Family: Poaceae) is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol corn silk extract of Z. mays (170 - 510 mg/kg) was investigated for anticonvulsant activity in mice using pentylene tetrazol and aminophylline-induced convulsion models to assess anticonvulsant activity. The extract was found to significantly (p < 0.005 -0.01) offer protection against PTZ- and aminophylline-induced convulsions in mice. The corn silk extract of Z. mays possesses anticonvulsant activity and this supports its use in ethnomedicine for the treatment of central nervous system disorders.

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Published
2018-12-24
How to Cite
Okokon, J. E., Davies, K., Nyong, E. E., & Udoh, A. E. (2018). Anticonvulsant activity of corn silk (Stigma maydis). Journal of Basic Pharmacology and Toxicology, 2(2), 6-10. Retrieved from https://scigreen.com/index.php/JBPT/article/view/49
Issue
Vol. 2 No. 2 (2018)
Section
Original Research Articles

Copyright (c) 2018 Jude Efiom Okokon, Koofreh Davies, Emmanuel E Nyong, Anwangabasi E Udoh

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

© The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).