Synthesis and biological evaluation of sulphonyl derivatives of naturally occurring chromone alkaloid of rohitukine as anticancer agents
Keywords:
Rohitukine, semisynthesis, Anticancer activity, Dysoxylum binectariferum, MCF-7, MDA-MB-231
Abstract
The present study deals with isolation of active constituent, rohitukine from the stem bark of Dysoxylum binectariferum, and synthesis of a series of its new sulphonyl derivatives aiming to enhance its therapeutic efficacy. Rohitukine has been isolated with more than 95% purity and ten new semisynthetic analogs have been prepared using different sulphonyl chlorides. These derivatives were evaluated for anticancer activity against MCF-7 (ER +ve) and MDA-MB-231 (ER -ve) breast cancer cell lines. Compounds K6, K8 and K10 showed significant activity against breast cancer cell lines at a concentration of 17.5 µM, 17 µM and 19 µM in MCF-7 and 20 µM, 9.8 µM and 28.5 µM in MDA-MB-231 respectively. These compounds induced significant apoptosis in MCF-cell line. Further work may enhance the anticancer activity.
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Published
2018-01-20
How to Cite
Mishra, S. K., Srivastava, P., Rath, S. K., Mahdi, A. A., Agarwal, S. K., & Lakshmi, V. (2018). Synthesis and biological evaluation of sulphonyl derivatives of naturally occurring chromone alkaloid of rohitukine as anticancer agents. Journal of Basic Pharmacology and Toxicology, 2(1), 1-7. Retrieved from https://scigreen.com/index.php/JBPT/article/view/42
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Section
Original Research Articles
Copyright (c) 2018 Vijai Lakshmi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
© The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).