Analgesic and Anti-inflammatory Potential of Ficus glomerata Leaves Fractions in Experimental Animals

  • Vishal S Gulecha SSDJ College of Pharmacy, Chandwad, Maharashtra, India
  • Manoj S Mahajan Department of Pharmacology, SNJB’S SSDJ College of Pharmacy, Neminagar, Chandwad. District, Nashik-423101, Maharashtra, India.
  • Rakesh A Khandare Department of Pharmacology, SNJB’S SSDJ College of Pharmacy, Neminagar, Chandwad. District, Nashik-423101, Maharashtra, India.
  • Chandrashekhar D Upasani Department of Pharmacology, SNJB’S SSDJ College of Pharmacy, Neminagar, Chandwad. District, Nashik-423101, Maharashtra, India.
Keywords: Ficus glomerata, cotton pellet, carrageenan, tail flick, acetic acid, writhing

Abstract

Present study evaluates the analgesic and anti-inflammatory potential of fractions of Ficus glomerata using various well established experimental models. Analgesic activity of F. glomerata was screened using acetic acid-induced writhing in mice and tail flick test in rats. Anti-inflammatory activity was done by carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. Ibuprofen and hydrocortisone were the reference standards employed in the study. Five fractions of F. glomerata (FGI, FGII, FGIII, FGIV and FGV) at the dose level of 20 and 40mg/kg, p.o were used. The fractions FGI (40mg/kg, p.o.) and FGIII (40mg/kg, p.o) were found to be effective inhibitors of carrageenan induced rat paw edema, cotton pellet granuloma formation and acetic acid induced writhing. The fractions FGI (20mg/kg, p.o.) and FGIII (20mg/kg, p.o.) were found to be more effective in increasing latency period in tail flick method. In conclusion, from the five different Fractions of F. glomerata tested, FGI and FGIII possess potent analgesic and antiinflammatory activities against different models of inflammation and pain.

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Published
2017-01-16
How to Cite
Gulecha, V. S., Mahajan, M. S., Khandare, R. A., & Upasani, C. D. (2017). Analgesic and Anti-inflammatory Potential of Ficus glomerata Leaves Fractions in Experimental Animals. Journal of Basic Pharmacology and Toxicology, 1(1), 13-17. Retrieved from http://scigreen.com/index.php/JBPT/article/view/6
Section
Original Research Articles