Psychopharmacological study on ethanol root extract of Panicum maximum

  • Jude Efiom Okokon Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • Anwanga E Udoh Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
  • John A Udobang Department of Clinical Pharmacology and Therapeutics, Faculty of Clinical Sciences, University of Uyo, Uyo, Nigeria
  • Koofreh O Davies Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
  • Emmanuel E Nyong Department of Clinical Pharmacology and Therapeutics, Faculty of Clinical Sciences, University of Uyo, Uyo, Nigeria
Keywords: Panicum maximum, Root extract, Anticonvulsant, CNS stimulant, Depressant

Abstract

Panicum maximum is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol root extract of Panicum maximum (137 - 547 mg/kg) was investigated for antidepressant and anticonvulsant activities in mice using open field and  forced swimming tests for depression models and aminophylline and pentylene tetrazol-induced convulsion for anticonvulsant activity evaluation. The extract was found to significantly (p < 0.05 - 0.01) increase the frequency of line crossing, rearing and walling activities of mice in open field test. The extract also significantly (p < 0.05 - 0.001) increased the duration of immobility of mice in forced swimming test. The root extract also protected the mice significantly (p < 0.05) against aminophylline and PTZ-induced convulsions. The root extract of P. maximum has depressant and anticonvulsant activities and this supports its use in ethnomedicine for the treatment of central nervous system disorders.
Published
2018-12-24
How to Cite
Okokon, J. E., Udoh, A. E., Udobang, J. A., Davies, K. O., & Nyong, E. E. (2018). Psychopharmacological study on ethanol root extract of Panicum maximum. Journal of Basic Pharmacology and Toxicology, 2(2), 1-5. Retrieved from http://scigreen.com/index.php/JBPT/article/view/48
Section
Original Research Articles