Psychopharmacological study on ethanol root extract of Panicum maximum
AbstractPanicum maximum is used in Ibibio ethnomedicine for the treatment of various diseases such as CNS disorders. The ethanol root extract of Panicum maximum (137 - 547 mg/kg) was investigated for antidepressant and anticonvulsant activities in mice using open field and forced swimming tests for depression models and aminophylline and pentylene tetrazol-induced convulsion for anticonvulsant activity evaluation. The extract was found to significantly (p < 0.05 - 0.01) increase the frequency of line crossing, rearing and walling activities of mice in open field test. The extract also significantly (p < 0.05 - 0.001) increased the duration of immobility of mice in forced swimming test. The root extract also protected the mice significantly (p < 0.05) against aminophylline and PTZ-induced convulsions. The root extract of P. maximum has depressant and anticonvulsant activities and this supports its use in ethnomedicine for the treatment of central nervous system disorders.
Copyright (c) 2018 Jude Efiom Okokon, Anwanga E Udoh, John A Udobang, Koofreh O Davies, Emmanuel E Nyong
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© 2017 The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).