Antinociceptive and antiinflammatory activities of the hydroethanolic extract of Clerodendrum volubile leaf
AbstractThe leaf of Clerodendrum volubile is used in the Traditional African Medicine (TAM) in the treatment of various diseases including painful and inflammatory conditions. This study was carried out to investigate the antinociceptive and antiinflammatory properties of the hydroethanolic leaf extract of Clerodendrum volubile (HeCV) in rodents. The antinociceptive activity was evaluated using the formalin, capsaicin and acetic acid-induced writhing assays in mice, while the carrageenan-induced paw edema and cotton pellet-induced granuloma formation tests in rats were used to investigate the antiinflammatory action. In the second phase of formalin induced nociception, the greatest effect (79.84% inhibition) was produced at the lowest dose of 100 mg/kg and had significant (p < 0.05) inhibition of nociception reaction. The effect was less and comparable to diclofenac 50 mg/kg (79.51%) but not significantly different (p < 0.05) from that of the effective dose of HeCV at 400 mg/kg. In respect of antiinflammatory activity, Clerodendrum volubile caused no significant (p < 0.05), but dose-dependent inhibition of edema development in carrageenan-induced inflammation and cotton pellet-induced granuloma formation in rat. Pretreatment of mice with sulpiride prevented HeCV induced antinociceptiion in mice writhing test. Findings from this work indicates that the hydroethanolic leaf extract of Clerodendrum volubile possesses antinociceptive and anti-inflammatory activities possibly mediated via peripheral and central mechanisms involving the activation of dopaminergic receptor. This justifies the use of the plant extract in TAM for the treatment of painful and inflammatory conditions.
Copyright (c) 2018 Olufemi Olatokunboh Amole, Akinyede A A, Alo K T
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© 2017 The Authors. Published by SciGreen Publications. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).